This study is to identify the hazard of ozone and to evaluate ozone effect that is flowed into the cabin when the airplane is flying at high altitude. For this purpose, it is studied that how ozone is generated in the air, what the effect on human body is due to the cabin ozone and what the design criteria is considering or preventing the ozone hazard. And, finally the regulations and means of compliance are studied and introduced to assure that the aircraft satisfies the design criteria related to ozone