Purpose: This study was performed to examine the relationship between caregiver burden and health-related quality of life (HRQOL) in family caregivers of stroke patients in the community. Methods: Subjects were 33 stroke patients who had a experience of hospitalization during last 1 year and their family. Data were obtained from personal interview by nursing students in October, 2003. We assessed the functional status of stroke patients, caregiver burden and the HRQOL of caregivers using SF-8. Results: A higher subjective burden was related to dependent functional status of patients than independent(P<.01). The independent cognitive function of stroke patients and good health of caregivers were related to high HRQOL of caregivers. PCS and MCS of HRQOL were negatively correlated to subjective burden, -.34(p<.01) and -.37(p<.05). Conclusion: We founded functional status of stroke patients. caregiver burden and HRQOL of caregivers were related to each other. To improve the HRQOL of caregiver, decreasing burden of caregivers and the functional status improvement of stroke patients must be considered.