This study was carried out to investigate the effects of Hyangsapyeongwisan(HP) on gastric mucosal lesions induced by indomethacin in mice. The control group consisted of gastro-inflammation elicited mice. The sample group consisted of mice given HP after onset of gastro-inflammation. In common morphological and histochemical change, various cell abnormalities were observed in the control group, such as mucous surface cell, peanut cell, surface epithelial cell, goblet cell abnormalities, all caused hemorrhagic erosion. The sample group was the same as the control group. In the immunohistochemical change, the distributions of COX-I, BrdU treated with HP were notably higher than those of the control group(p<O.05). The distributions of TUNEL, $NF-{kappa}B$, COX-2, PKC, IL-12B in mice treated with HP were notably lower than those of the control group(p<O.05). The above results support a role for Hyangsapyeongwisan in treating gastric mucosal lesions.