Objectives : The purpose of this clinical study is to evaluate the clinical efficacy of Pasaekhwalhyeol-Tang on acute headache from acute cerebral infarct. Methods : Pasaekhwalhyeol-Tang was prescribed to 15 acute cerebral infarct patients for two weeks. Symptoms were checked and VAS(Visual Analog Scale) scores were kept every week. Results : After prescription of Pasaekhwalhyeol-Tang, VAS scores on headache and accompanying symptoms decreased. No significant changes were shown in laboratory findings. As for the laboratory findings, ALT showed an upward tendency within a week and increased over normal values in two cases(13%). But two weeks later, ALT decreased within normal values. And the mean serum level was within normal values and the other hepatic enzymes did not increase over normal values in either week nor week 2. Conclusions : Results suggest that Pasaekhwalhyeol-Tang is effective in reducing the severity of acute headache from acute cerebral infarct.