This study was designed to evaluate the effects of oriental medicine and acupuncture therapy on a chronic renal failure patient suffering complications from diabetes mellitus. Methods: The clinical data was analyzed on a patient with chronic renal failure complicated by diabetes mellitus whose main symptoms were edema and numbness of lower limbs, anorexia, indigestion, nausea, vomiting, and general weakness. The patient was admitted to the internal medicine department of Wonkwang University Oriental Jeonju Medicine Hospital on July 31, 2004, and remained until August 17, 2004. He was treated with herbal medicine(Palmijiwhangtanggamibang) and acupuncture therapy. Results: After treatment, improvement was seen in symptoms and laboratory examinations(creatinine clearance). Conclusions: This study suggests that oriental medicine therapy is significantly effective in the treatment of a chronic renal failure complicated by diabetes mellitus.