The purpose of this study was to evaluate mushroom Tyrosinase inhibitory activity of Cuscuta japonica Choisy and C. australis R.Be. The experimental materials were expressed juice from their stems and flowers, both water and ethanol extracts, their seeds, and two kinds of commercially available cosmetic packing Wontosa and Bupjetosa (made from seeds of C. japonica). The 50% inhibitory concentration $(IC_{50})$ of C. Japonica juice was 5.4 mg/ml. However, C. australis juice showed negligible mushroom tyrosinase inhibitory activity. The $IC_{50}$ of water extracted C. japonica seed was $54.0;{mu}g/ml$, water extracted product of Wontosa $50.0;{mu}g/ml$ and Bupjetosa $40;{mu}g/ml$. The $IC_{50}$ of ethanol extracted C. japonica seed was $10;{mu}g/ml$, Wontosa $10;{mu}g/ml$ and Bupjetosa $20;{mu}g/ml$.