Generally, structural optimization is carried out based on external static loads. All forces have dynamic characteristics in the real world. Mathematical optimization with dynamic loads is extremely difficult in a large-scale problem due to the behaviors in the time domain. In practical applications, it is customary to transform the dynamic loads into static loads by dynamic factors, design codes, and etc. But the optimization results with the unreasonably transformed loads cannot give us good solutions. Recently, a systematic transformation has been proposed as an engineering algorithm. Equivalent static loads are made to generate the same displacement field as the one from dynamic loads at each time step of dynamic analysis. Thus, many load cases are used as the multiple loading conditions which are not costly to include in modem structural optimization. In this research, the proposed algorithm is applied to the optimization of flexible multibody dynamic systems. The equivalent static load is derived from the equations of motion of a flexible multibody dynamic system. A few examples that have been solved before are solved to be compared with the results from the proposed algorithm.