Cellulose and N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride (HTCC) were solution blended using 50% N-methylmorpholine-N-oxide (NMMO) aqueous solution as a solvent. The blend fibers of cellulose/HTCC having different HTCC content could be obtained via dry-jet wet spinning process at the take-up speeds of 3～18 m/min. The mechanical, thermal, and structural properties of the blend fibers were investigated. High take-up speed resulted in high tenacity and low elongation as expected. Dry tenacity values did not change with increasing HTCC content. Wet tenacity values, on the other hand, decreased significantly compared to dry ones, the effect being more pronounced with increasing HTCC content. The presence of HTCC in the blend fiber did not affect the crystalline structure of cellulose, however it decreased the crystallinity index. As the take-up speed increased, crystallinity index and crystallite orientation factor of the cellulose in the blend fiber increased. The blend fibers showed lower degradation temperatures than regenerated cellulose. They can be dyed with acid dye, and the color strength (K/S) of the dyed samples increased with increase in HTCC content.