Experiments have been conducted in order to make comparisons of characteristics of a R410a cycle with a R22 cycle in terms of cooling capacity and coefficient of performance (COP). The parameters examined in the present work include air flow rate, indoor and outdoor air temperatures, and indoor relative humidity. These two refrigeration cycles constructed for this study share all components except compressor, accumulator, oil separator, and piping. The measurements were made using a psychrometric calorimeter. The experimental results show that the R410A cycle has several advantages for indoor units while the R22 cycle yields better performance for outdoor units.