The present study investigates the fire suppression characteristics using a water mist fire suppression system. Numerical simulations of fire suppression with water mist are performed with considering the interaction of fire plume and water spray. The predicted temperature fields of smoke layer are compared with those of measured data. Numerical results agree with the experimental results within $10^{circ}C$ in the case without water mist. In the case of fire suppression with water mist, numerical results do not predict well for temperature field in the gradual cooling region after water mist injection. But the predicted results of initial fire suppression are in good agreement with those of measured data. The reason for the discrepancy between predicted and measured data is due to the poor combustion modeling during the injection of water mist. More elaborate models for numerical simulation are required for better predictions of the fire suppression characteristics using water mist.