When material properties depend much on positions in a material or it is difficult to make test specimens from a material or component, an instrumented indentation test described in ISO 14577-1, 14577-2 or KS B 0950 can be used to measure material properties and damage. In this study, first of all, the principals of the instrumented indentation test, KS B 0950 are introduced and yield strengths, tensile strengths and work hardening exponents of base materials, heat affected zones and weld materials are measured. In addition, the influence of post-weld heat treatment on the material properties is investigated. Finally the fatigue lift of butt welded specimens are evaluated by the local strain approach. To calculate local strains and stresses, elasto-plastic finite element analysis is conducted using the measured properties.