An experimental study on the pressure drop during flow boiling for pure refrigerants Rl34a and R123, and their mixture was carried out in a uniformly heated horizontal tube. Tests were run at a pressure of 0.6㎫ and in the ranges of heat flux 5-50㎾/$m^2$, vapor quality 0-100 percent and mass velocity of 150-600 kg/$m^2$s. Generally, the two-phase frictional multiplier is used to predict the frictional pressure drop during the two-phase flow boiling. The obtained results have been compared to the existing various correlations for the two-phase multiplier. Also, the frictional pressure drop was compared to a few available correlations; The Lockhart-Martinelli correlation considerally overpredicted the frictional pressure drop data for mixture as well as pure components in the entire mass velocity ranges employed in the present study, while the Chisholm correlation underpredicted the present data. The Friedel correlation was found to satisfactorily correlate the frictional pressure drop data except for a low quality region.