A numerical optimization procedure for the shape of three-dimensional channel with angled ribs mounted on one of the walls to enhance turbulent heat transfer is presented. The response surface method is used as an optimization technique with Reynolds-averaged Wavier-Stokes analyses of flow and heat transfer. SST turbulence model is used as a turbulence closure. Computational results for local heat transfer rate show reasonable agreements with experimental data. The pitch-to-height ratio of the rib and rib height-to-channel height ratio are set to be 9.0 and 0.1, respectively, and width-to-rib height ratio and attack angle of the rib are chosen as design variables. The objective function is defined as a linear combination of heat-transfer and friction-loss related terms with weighting factor. Full-factorial experimental design method is used to determine the data points. Optimum shapes of the channel have been obtained in the range from 0.0 to 0.1 of weighting factor.