The numerical methods including the performance analysis and the noise prediction of the centrifugal compressor impeller are coupled with the optimization design skill, which consists of response surface method, statistical approach, and genetic algorithm. The flow-field Inside of a centrifugal compressor is obtained numerically by solving Wavier-Stokes equations. and then the propagating noise is estimated from the distributed surface pressure by using Ffowcs Williams-Hawkings formulation. The quadratic response surface model with D-optimal 3-level factorial experimental design points is constructed to optimize the impeller geometry for the advanced centrifugal compressor. The statistical analysis shows that the quadratic model exhibits a reasonable fitting quality resulting in the impeller blade design with high performance and low far-field noise level. The influences of selected design variables, objective functions, and constraints on the impeller performance and the impeller noise are also examined as a result of the optimization process.