Purpose: The purpose of this study was to identify the relationship among perceived stress, ways of coping, and health promoting behaviors in patients with chronic cardiovascular disease(CCVD). Method: Data was collected by questionnaires from 436 patients with CCVD in a General Hospital in Seoul. The data was analyzed using descriptive statistics, Pearson correlation coefficients, and stepwise multiple regression. Result: The health promoting behavior showed a significant positive correlation with self-efficacy and social support. Also, the health promoting behavior showed a significant negative correlation with perceived stress and symptoms of stress. The stepwise multiple regression analysis revealed that the most powerful predictor of health promoting behaviors was symptoms of stress. Conclusion: A combination of symptoms of stress, social support, self-efficacy, and perceived stress account for 41% of the variance in health promoting behaviors of patients with CCVD. Data from this study suggest that symptoms of stress, social support, ways of coping, and perceived stress are significant influencing factors on health promoting behaviors of patients with CCVD.