End-milling has been used widely in industrial system because it is effective to a material manufacturing with various shapes. Recently the end-milling processing is needed the high-precise technique with good surface roughness and rapid time in precision machine part and electronic part. The optimum mechanical vibration of main spindle, surface roughness and cutting temperature have an effect on end-milling condition such as, cutting direction, revolution of spindle, feed rate and depth of cut, etc. Therefore, this study carried to decide the working condition for optimum mechanical vibration of main spindle, surface roughness and cutting temperature using design of experiments, ANOVA and characteristic function. From the results of experimentation, mechanical vibration has an effect on revolution of spindle, radial depth of cut, and axial depth of cut. The surface roughness has an effect on cutting direction, revolution of spindle and depth of cut. And then the optimum condition used design of experiments is upward cutting In cutting direction, 600 rpm in revolution of spindle, 240 mm/min in feed rate, 2 mm in axial depth of cut and 0.25 mm in radial depth of cut. By design of experiments and characteristic function, it is effectively represented shape characteristics of mechanical vibration, surface roughness and cutting temperature in end-milling.