In this paper, we describe an intelligent monitoring and control system for pick-up/delivery service. This system applies geographical information system(GIS), global positioning system(GPS) and wireless communication technologies for managing pick-up/delivery operations more effectively. It consists of three subsystems, pick-up/delivery sequence planning system, pick-up/delivery monitoring system, and PDA execution system. Pick-up/delivery sequence planning system generates routes and schedules for pick-up/delivery using GIS and optimization techniques. Pick-up/delivery monitoring system monitors current positions of vehicles and actual pick-up/delivery results as compared with planned routes and visit times, while PDA execution system transmits information for vehicles positions and actual pick-up/delivery results using GPS and wireless communication technologies. The intelligent monitoring and control system is currently being used for the pick-up parcel service in a local post office of Korea Post.