The chromatographic separation of a methylene chloride extract of Artemisia rubripes led to the isolation of a new sesquiterpene lactone (3), together with four known compounds, a coumarin (2) and three terpenes (1, 4, and 5). Their structures were characterized to be $1{eta},6{alpha}$- dihydroxy-4(15)-eudesmene (1), scopoletin (2), $1{alpha},4{eta}-dihydroxy-8{alpha}$-acetoxy-guaia-2,10(14), 11(13)-triene-6,12-olide (3), $1{alpha},4{eta}$ -dihydroxy-8${alpha}$-acetoxy-guaia-2,9,11(13)-triene-6,12-olide (4), and $eta$ -sitosterol-3-O-${eta}$-D-glycoside (5) by spectroscopic means.