A wavelet based ECG data compression has become an attractive and efficient method in many mobile tele-cardiology applications. But large data size required for high compression performance leads a serious delay. In this paper, new wavelet compression method with minimum delay is proposed. It is based on deciding the type and compression ratio(CR) of block organically according to the standard deviation of input ECG data with minimum block size. Compression performances of the proposed algorithm for different MIT ECG Records were analyzed comparing other ECG compression algorithm. In addition to the processing delay measurement, compression efficiency and reconstruction sensitivity to error were also evaluated via random noise simulation models. The results show that the proposed algorithm has both lower PRD than other algorithm on same CR and minimum time in the data acquisition, processing and transmission.