In this article, a genetic algorithm based optimum design method is presented for non-linear steel frames with semi-rigid connections. The design algorithm obtains the minimum weight frame by selecting suitable sections from a standard set of steel sections such as European wide flange beams (i.e., HE sections). A genetic algorithm is employed as optimization method which utilizes reproduction, crossover and mutation operators. Displacement and stress constraints of Turkish Building Code for Steel Structures (TS 648, 1980) are imposed on the frame. The algorithm requires a large number of non-linear analyses of frames. The analyses cover both the non-linear behaviour of beam-to-column connection and $P-{Delta}$ effects of beam-column members. The Frye and Morris polynomial model is used for modelling of semi-rigid connections. Two design examples with various type of connections are presented to demonstrate the application of the algorithm. The semi-rigid connection modelling results in more economical solutions than rigid connection modelling, but it increases frame drift.