For a long road tunnel, a tunnel ventilation system may be used in order to reduce the pollution level below the required level. To control the tunnel pollution level, a closed loop control algorithm may be used. The feedforward prediction algorithm and the cascade control algorithm were developed to regulate the CO level in a tunnel. The feedforward prediction algorithm composed of the traffic estimation algorithm and the CO density prediction algorithm, and the cascade control algorithm composed of the jet fan control algorithm and the air velocity setpoint algorithm. The verification of control algorithms was carried out by dynamic models developed from the actual tunnel data. The simulation results showed that control algorithms developed for this study were effective for the control of the tunnel ventilation system.