Estrogens are critical to the functioning and maintenance of a diverse array of tissues and physiological systems in mammals. The actions of estrogen on such classical targets as the reproductive tract, gonads, mamary tissue, and hypothalamic/pituitary axis have been well characterized. A role in nonreproductive tissues, such as maintenance of bone mineral density and cardiovascular health in woman, as has been described. There were ne significant differences in the average of body weights, testis weights, among the experimental groups. The lumen of rate testis began to dilate from the day 8 and continued to the 59 post-treatment. The average diameter of dilate of rate testis in ICI 182,780 treated group increased 2.3-fold compared to the control group. Epithelical cell height in the rate testis of the treated mice decreased all the time periods, compared to the control.