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정신분열병의 시각자극 사건유발전위 P300에 대한 연구
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  • 정신분열병의 시각자극 사건유발전위 P300에 대한 연구
저자명
오동훈,남정현,안동현,김석현,최준호,Oh. Dong-Hoon,Nam. Jung-Hyun,Ahn. Dong-Hyun,Kim. Seok-Hyun,Choi. Joon-Ho
간행물명
생물정신의학
권/호정보
2004년|11권 1호|pp.40-48 (9 pages)
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대한생물정신의학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Objective:Event-related potentials(ERPs) are electrical changes recorded at the surface of the scalp in response to stimulus presentation, and their latency and amplitude change according to cognitive processes. Through past studies of the auditory ERP in schizophrenia, the P300 has been reported to be statistically smaller and delayed in schizophrenia than comparison groups. However, studies of the visual ERP have not been systematically examined. The present study was designed to investigate the visual P300 in patients with schizophrenia and normal controls and to compare the pattern of P300 between them. Methods:The subjects were composed of patients(N=22) with schizophrenia by DSM-IV and normal controls(N=22). The visual ERPs were measured by the visual continuous performance test. P300 amplitude and latency measured on 5 scalp electrodes(Fz, Cz, Pz, $T_7$, $T_8$) were compared between patients and controls. Results:The P300 latencies measured on Fz, Cz, Pz, and $T_7$ electrodes were significantly longer in patients than controls(p<0.05). The P300 amplitudes in patients were smaller than controls. However, the difference between them was not statistically significant. Conclusion:Analysis of the visual ERPs showed that the P300 latency is significantly delayed and the P300 amplitude is slightly smaller in patients than controls. These results are similar to established studies of the auditory P300 in schizophrenia.