A new approach based on vector field clustering for tool path optimization of 5-axis CNC machining is presented in this paper. The strategy of the approach is to produce an efficient tool path with respect to the optimal cutting direction vector field. The optimal cutting direction maximizes the machining strip width. We use the normalized cut clustering technique to partition the vector field into clusters. The spiral and the zigzag patterns are then applied to generate tool path on the clusters. The iso-scallop method is used for calculating the tool path. Finally, our numerical examples and real cutting experiment show that the tool path generated by the proposed method is more efficient than the tool path generated by the traditional iso-parametric method.