A model was proposed for investigating the particle removal from suspension with particles of different sizes by deep-bed filtration, and the collection efficiency was predicted by computer simulation. Deposited particles on the pore surface may act as additional collector and reduce the pore size, which contribute to the improved collection efficiency with increase of deposition. Computer experiments for suspension of particles of three sizes and its equivalent size of mono particles were carried out and compared. The collection efficiency of suspension with poly-dispersed particles shows higher efficiency than that of suspension with mono-dispersed particles. Also the collection efficiency of smell particle of mixture is higher that that of same uniform size particles.