Alopecia is an increasing disease recently. Alopecia has social and psychological influence on the alopecia patients. But there is no perfect treatment of alopecia. Authors performed clinical study to evaluate the therapeutic effects of herbal soap Sangmogen in patients with alopecia. Twenty patients with alopecia were included in this study. The patients shampooed with herbal soap Sangmogen everyday. Efficacy was determined by investigating counts of hair, terminal hair, vellus hair, hair follicle, hair pull test, erythema, scale and fissure. After a experiment, self-assessment was checked. As the result of the study, we found that a significant effect was observed. So we concluded that herbal soap Sangmogen has a clinical effect on the alopecia.