A survey was performed for 2 weeks in October 2004 in order to examine the effects and changes of far infrared and anion of office workers aged 40 and older before and after wearing the underwear. In the survey, questionnaires and photoplethysmography were used to measure the difference between the two tests conducted with one week interval. The findings could be summed up as follows: 1. There was no statistically significant difference in changes of vascular aging points and photoplethysmogram wave form before and after wearing the far infrared and anion underwear but the points showed the increasing tendency(p>0.05). 2. A statistically significant difference was confirmed since the total points of each item in the questionnaires increased after wearing the underwear(p<0.001). 3. In connection with the systemic symptoms, a significant difference was found with increased points in all items except for no. 6 after wearing the underwear(p<0.05). 4. With regard to the difference before and after wearing the underwear depending on the Kidney symptoms, there was a significant difference with increased points in all items except for item no. 1 after wearing the underwear(p<0.05). In conclusion, to put on the underwear with effect of far infrared and anion is believed to smooth metabolism and blood circulation, contributing by thus to promoting health and preventing disease. Further studies with wider sampling of subjects are requested to diversify and refine the findings from this sectional study.