Objectives : The aims of this study were to observe how effect bell sound, water sound and drum sound have on origin regions for acupuncture of twelve meridians by yangdorak diagnosis, and to practice it clinically. Methods : Firstly, ire measured origin regions for acupuncture of twelve meridians by yangdorak diagnosis, after we relieved a subject for 10 minutes. Secondly, we measured origin regions for acupuncture of twelve meridians by yangdorak diagnosis, after a subject listened to bell sound, water sound and drum sound for 3 minutes. Results : Through testing the effects of bell sound, water sound and drum sound on numerical values of origin regions for acupuncture of twelve meridians by yangdorak diagnosis, we had follows; 1. On bell sound, the numerical values of origin regions for acupuncture of twelve meridians by yangdorak diagnosis descended from 38.8 to 28.8 in left, and from 40.4 to 30.8 in right. 2. On water sound, the numerical values of origin regions for acupuncture of twelve meridians by yangdorak diagnosis descended from 55.4 to 39.4 in left, and from 56.0 to 41.9 in right. 3. On drum sound, the numerical values of origin regions for acupuncture of twelve meridians by yangdorak diagnosis descended from 39.1 to 30.1 in left, and from 38.4 to 38.0 in right. Conclusion : Through testing the effects of tone sounds on numerical values of origin lesions for acupuncture of twelve meridians by yangdorak diagnosis, we confirmed that change of tone colors go by five elemental theory rule and have effect on enery and blood metabolism.