Objectives : This study is designed to observe anaphylatic reaction In two patients, who visited Dong-Eui University Oriental Medicine Center for Bee-Venom Acupuncture. Methods : Anaphylaxis is a clinical syndrome cheracterized by the acute system reaction of multiple organ systems to an IgE-mediated immunologic mediator release in previously sensitized individuals. Anaphylatic reaction of two patients treated by Bee-Venom Acupuncture were observed in order to analysis the clinical form. Results & Conclusion : STZ One case of Anaphylatic reaction was expressed clinically hypotension drowsy mentality, dizziness muscle contraction and so on. The other case was expressed ulticaria, itching sensation, nausea and erythema. Especially ulticaria erythema are end points of increased vascular permeability and vasodilatation at the extreme of the clinical spectrum.