Nowadays people suffer from the excessive stress, emotional disorder, lack of sleepness, overeating of rich fatty diet and irregular schedule. These things accumulate Fire inside humanbody through many ways. Fire, then, brings out many kinds of disease. How to treat Fire is important theme of the medicine. Liu Wansu studied Fire as a important pathogenic factor. He evolved his theory about the relationship between the Xuanfu(玄府)- the sweat, Six Qi, emotional disorder and the climate condition and Fire. He payed great efforts to diagnose accurately and treat the disease on the ground of the theory based on The Yellow Emperors‘ Internal classic.