The chromatographic separation of methanolic extract from the twigs of Ilex macropoda (Aquifoliaceae) led to the isolation of three hemiterpenes, and their chemical were elucidated by physico-chemical and spectroscopic analysis. Their structures were characterized as 4,5-dihydroxyprenyl caffeate (1), $4-(6-O-caffeoyl-{eta}-D-glucucopyranosyloxy)-5-hydoxyprenyl$ caffeate (2), and $4-{eta}-D-glucucopyranosyloxy-5-hydroxyprenyl$ caffeate (3), respectively. Compound 1 was isolated for the first time from plant.