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Compaction Simulator Study on Pectin Introducing Dwell Time
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  • Compaction Simulator Study on Pectin Introducing Dwell Time
  • Compaction Simulator Study on Pectin Introducing Dwell Time
저자명
Kim. Hyun-Jo,Venkatesh. Gopi
간행물명
藥劑學會誌
권/호정보
2005년|35권 4호|pp.243-247 (5 pages)
발행정보
한국약제학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Although many scientists have used pectin, its feasibility in terms of tablet manufacturability with a high speed machine has never been evaluated. Therefore, compactibility of different pectin types for large scale tableting operation has been evaluated. The compactibility behavior of powder pectins was studied by a compaction simulator. It was found that pectin on its own does not produce tablets of acceptable quality even at a punch velocity as low as 20 rpm (e.g. low tensile strengths, capping and lamination irrespective of applied compression force). Thus, dwell time was introduced and more hard compact was produced as relaxation time in die increases. It was concluded that frequent structural failure observed in both pectin types was due to lack of plastic deformation, poor compactibility and high elastic recovery.