Several heavy metals are known to give some kinds of mental retardation although abnormal X-chromosome is closely connected with genetic disease such as mental retardation. This study dealt with the influence of minerals in the hair of mental retardation people. Minerals were analyzed by Inductively Coupled Plasma Mass Spectrometer (Sciex Elan 6100, Perkin-Elmer corporation, Foster, CA, USA). The nutritional elements such as Ca, Na, K were higher level (p<0.01) in normal group than in the mental retardation group. The toxic elements such as Cd (p<0.01) and As were higher level in the mental retardation group than in normal group. But Pb is not significant difference among the all groups including normal group.