The integrity of nuclear piping systems has to be maintained sufficiently all the times during operation. In order to maintain the integrity, reliable assessment procedures including fracture mechanics analysis, etc, are required. Up to now, the integrity assessment has been performed using conventional deterministic approach even though there are lots of uncertainties to hinder a rational evaluation. In this respect, probabilistic approach is considered as an appropriate method for piping system evaluation. The objectives of this paper are to develop a probabilistic assessment program using reliability index and simulation technique and to estimate the damage probability of wall-thinned pipes in secondary systems. The probabilistic assessment program consists of three evaluation modules which are first order reliability method, second order reliability method and Monte Carlo simulation method. The developed program has been applied to evaluate damage probabilities of wall-thinned pipes subjected to internal pressure, global bending moment and combined loading. The sensitivity analysis results as well as prototypal evaluation results showed a promising applicability of the probabilistic integrity assessment program.