Boiling heat transfer characteristics of a two-phase closed thermosyphons with various helical grooves are studied experimentally and a mathematical correlation is developed to predict the performance of such thermosyphons. The study focuses on the boiling heat transfer characteristics of two-phase closed thermosyphons with copper tubes having 50, 60, 70, 80, 90 internal helical grooves. A two-phase closed thermosyphon with plain copper tube having the same inner and outer diameter as those of grooved tubes is also tested for comparison. Water, methanol and ethanol are used as working fluid. The effects of the number of grooves, various working fluids, operating temperature and heat flux are investigated experimentally. From these experimental results, a mathematical model is developed. In the present model, boiling of liquid pool in the evaporator is considered for the heat transfer mechanism of the thermosyphons. And also the effects of the number of grooves, the various working fluids, the operating temperature and the heat flux are brought into consideration. A good agreement between the boiling heat transfer coefficient of the thermosyphon estimated from experimental results and the predictions from the present mathematical correlation is obtained. The experimental results show that the number of grooves, the amount of the working fluid and the various working fluids are very important factors for the operation of thermosyphons. Also, the thermosyphons with internal helical grooves can be used to achieve some inexpensive and compact heat exchangers in low temperature.