A numerical method is developed for the hydroelastic response of the Very Large Floating Structure considering the sea-bottom topography. The sea-bottom effects on the hydroelastic response of the floating structure is studied. The sea-bottom topography should be considered when the floating structure is constructed near the shore. To investigate the sea-bottom effects, four different sea-bottom topographies are considered in this study. finite-element method based on the variational formulation is used in the fluid domain, The pontoon-type floating structure is modeled as the Kirchhoff plate. The mode superposition method is adopted for the hydroelastic behavior of the floating structure.