A high-rise residential building experienced stack effect problems during the winter such as difficulties in opening residential entrance doors and whistling noise from elevator doors generated by airflow. Field measurements were carried out on the building and the problems were verified by the analysis of the measurement results from three points of view: the total stack pressure difference, pressure distribution on each floor, and the location of the neutral pressure level. Based on the analysis of the three key parameters, possible solutions were proposed, such as zoning vertical shafts, lessening the airflow from the entrance doors on basement floors and lobby floor by installing vestibules, improving the airtightness of exterior walls, and installing separation doors where the problems occur. Simulations of proposed solutions were conducted and the effects of reducing the pressure difference were evaluated. Stack effect problems in a high-rise residential building were verified through field measurements and could be mitigated by the solutions which were drawn from the analysis of the field measurements and the simulation results.