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서지반출
건강한 지원자에 있어서 염산테르비나핀 함유 라미실정과 무조날정의 약물동력학적 비교
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  • 건강한 지원자에 있어서 염산테르비나핀 함유 라미실정과 무조날정의 약물동력학적 비교
  • Pharmacokinetic Comparison of Lamisil Tablet and Muzonal Tablet Containing Terbinafine HCl in Healthy Volunteers
저자명
최한곤,용철순,이종달,우종수,이경희,유봉규,Choi. Han-Gon,Yong. Chul Soon,Rhee. Jong-Dhal,Woo. Jong-Soo,Lee. Kyung Hee,Yoo. Bong Kyu
간행물명
약학회지
권/호정보
2005년|49권 4호|pp.255-259 (5 pages)
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

Financial standing of National Health Insurance has been experiencing a grave deterioration during the last 4-5 years, and the yearly amount paid by the insurance for drug expense rose up to 4 trillion won recently. Furthermore, the ratio of drug expenses in the total expenditure of the insurance reached about $25\%$, showing the tendency to be levelled off. As a measure to improve the financial deterioration of the insurance and to encourage generic substitution among the health professionals, we compared pharmacokinetic parameters of brand name drug (Lamisil) and generic drug (Muzonal) containing terbinafine HCl in healthy volunteers. The area under the curve (AUC) of the two drugs showed $2220.4pm784.7;and;2143.1pm861.6hr{cdot}ng/ml$ in the corresponding order and no statistically significant difference was identified. The peak concentration $(C_{max})$ of the generic drug demonstrated $566.6pm246.2 ng/ml$ compared to $550.8pm204.0$ of brand name drug, which was not significantly different either. Time to reach peak concentration showed about 6 minutes difference between the drugs, which has no clinical significance to the treatment of dermatomycosis and dermatophytosis.