To increase the efficiency of an applicator during microwave hyperthermia therapy, first, the length from the antenna end to a slot is varied to get the optimal matching of the characteristic impedance at the frequency of 2.45 GHz. Using the electric and thermal constants of biological tissue, we compose a phantom to calculate temperature increment as well as the resonance characteristics and the SAR distributions. The proposed 3-slot sleeve antenna inserted in an applicator plays an effective role in increasing the therapy size in the view of heating performance as electromagnetic energy tends to concentrate on not feed point direction but treatment area. The SAR is then used in combination with a finite difference heat transfer equation to determine the temperature distribution. Also, in order to shorten treatment time and increase therapy size, a square-array structure is suggested and analyzed.