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Drug Release Behavior of Poly($varepsilon$-caprolactone )-b-Poly( acrylic acid) Shell Crosslinked Micelles below the Critical Micelle Concentration
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  • Drug Release Behavior of Poly($varepsilon$-caprolactone )-b-Poly( acrylic acid) Shell Crosslinked Micelles below the Critical Micelle Concentration
  • Drug Release Behavior of Poly($varepsilon$-caprolactone )-b-Poly( acrylic acid) Shell Crosslinked Micelles below the Critical Micelle Concentration
저자명
Hong. Sung Woo,Kim. Keon Hyeong,Huh. June,Ahn. Cheol-Hee,Jo. Won Ho
간행물명
Macromolecular research
권/호정보
2005년|13권 5호|pp.397-402 (6 pages)
발행정보
한국고분자학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

To explore the potential of shell crosslinked micelle (SCM) as a drug carrier, the drug release behavior of poly($varepsilon$-caprolactone)-b-poly(acrylic acid) (PCL-b-PAA) SCMs was investigated. PCL-b-PAA was synthesized by ring opening polymerization of $varepsilon$-caprolactone and atom transfer radical polymerization of tert-butyl acrylate, followed by selective hydrolysis of tert-butyl ester groups to acrylic acid groups. The resulting amphiphilic polymer was used to prepare SCMs by crosslinking of PAA corona via amidation chemistry. The drug release behavior of the SCMs was studied, using pyrene as a model drug, and was compared with that of non-crosslinked micelles, especially below the critical micelle concentration (CMC). When the shell layers were crosslinked, the drug release behavior of the SCMs was successfully modulated at a controlled rate compared with that of the non-crosslinked micelles, which showed a burst release of drug within a short time.