Due to the difficulties associated with the supply of steel plates, hot rolled coil (Steel grade: SM490A) is considered fur structural materials in replace of the existing SWS50A-M1. However, it is found that SM490A exhibits a significant anisotropy in terms of impact energy with respect to transverse and longitudinal directions. In this study, an experimental investigation is carried out to examine the relationship between the anisotropy in impact values and the fatigue strengths of SM490A with respect to the rolling direction of test specimens. All test specimens failed around 1,500,000 cycles regardless of the test specimen direction. Therefore, it is found that the anisotropy in impact energy is not related to the fatigue strength of the materials considered in this study. However, the transverse direction specimen showed more rapid brittle fracture mode compared to that of longitudinal direction specimen, and this appears to be related to the lower impact values in transverse direction.