In vitro, MAO-A activity was inhibited $16-25\%$, and MAO-B activity was inhibited $20-50\%$ by SE treatment (12.5, 25 and $50{mu}g$). In vivo, male C57BL/6 mice received intraperitoneal injection of SE (20 mg/kg/day) for 14 days. The results showed that MAO-A activity of pre-SE-treatment mice brain was inhibited in whole brain, cerebral cortex, substantia nigra. MAO- B activity of pre-SE-treatment mice brain was inhibited in substantia nigra and cerebellum than saline-treated control group. These results suggest that SE inhibits MAO activity in vivo, which would be expected to results in anti -depressive and neuroprotective effects.