In order to minimize warping deformation which is an essential factor in the failure of injection molding parts, this study proposes an optimization design method fer determining design variables of injection molding parts. First, using a commercial package program for injection molding analysis, namely, Computer Aided Plastics Application(CAPA), we investigate the effects of parameters of injection molding process. Next, an optimum design process is established by interfacing CAPA to PQRSM embedded in EMD10S, a design framework developed by the conte. of innovative Design Optimization Technology(iDOT). PQRSM is a very efficient sequential approximate optimization algorithm. Optimum design results demonstrate the effectiveness of the design method suggested in this study by showing that the results of the optimum design is better than those of the initial design. It is believed that the proposed methodology can be applied to other injection molding design applications.