A design procedure for a ship with minimum total resistance has been developed using a numerical optimization method called SQP (Sequential Quadratic Programming) to search for optimized hull form and CFD(Computational Fluid Dynamics) technique. The friction resistance is estimated using the ITTC 1957 model-ship correlation line formula and the wave making resistance is evaluated using a potential-flow panel method based on Rankine sources with nonlinear free surface boundary conditions. The geometry of hull surface is represented and modified using B-spline surface patches during the optimization process. Using the Series 60 hull ($C_B$ =0.60) as a base hull, the optimization procedure is applied to obtain an optimal hull that produces the minimum total resistance for the given constraints. To verify the validity of the result, the original model and the optimized model obtained by the optimization process have been built and tested in a towing tank. It is shown that the optimal hull obtained around $13\%$ reduction in the total resistance and around $40\%$ reduction in the residual resistance at a speed tested compared with that of the original one, demonstrating that the present optimization tool can be effectively used for efficient hull form designs.