Purpose: This study was done to investigate satisfaction with life in adolescents, and to identify factors affecting satisfaction with lift for adolescents. Method: The participants were 540 adolescents. Data were collected through self-report questionnaires which were constructed to include satisfaction with life, mental health, family adaptability and cohesion, and school adjustment. The data were analyzed using the SPSS program. Results: Satisfaction with life in adolescents correlated with mental health, family adaptability and cohesion, and school adjustment. Satisfaction with lift in adolescents was significantly different according to scholastic achievement, parents being alive, economic level of family, and types of family cohesion and adaptability. Significant predictors influencing satisfaction with life in adolescents were school adjustment, family cohesion, mental health, and economic level of family, and these predictors accounted for $28.3\%$ of the variance in satisfaction with lift. Conclusion: The above findings indicate that satisfaction with life in adolescents is influenced by mental health, family function, and school adjustment. Therefore when nursing interventions are developed to improve satisfaction with life in adolescents, these factors need to be considered.