In this study, we propose a methodology of mating it easy to integrate the heterogeneous and distributed information of e-Business environments with the semantic web components , knowledge representation, ontology and agents. It is based on a collaborative interoperable environment, which should be constructed by meta-modeling and employing agents , and the syntactic/semantic integration. We adopt OWL(Web Ontology Language) to specify ontology in a layered architecture for each agent to use, which is based on the IRDS (Information Resource Dictionary Standard) framework. And we give an illustrative example using the terms from PSL(Process Specification Language)-ontology. By defining, managing and sharing resources and business-processes on the proposed framework, it could be possible to get rid of the cause of redundancy and inconsistency.