For high speed railway vehicles, we consider a vibration of flexible track/wheel system. It is very important to deal with the complex phenomena of high-speed vehicles that can be occurred in the vertical vibration of the system. From a viewpoint of multibody dynamics, this kind of problem needs accurate analysis because the system includes mutual dynamic behaviors of rigid body and flexible body. The simulation technique for the complex problems is also discussed. We consider the high-speed translation, rail elasticity, elastic supports under the rail and contact rigidity. Eigen value analysis is also completed to verify the mechanism of the coupled vertical vibration of the system.