Engineered nanoparticles exhibit a variety of unique and tunable chemical and physical properties. These unique properties make the nanoparticles central components and widespread potential applications in nanoindustry. However, the potential toxicities of nanoparticles have not been fully evaluated. Recently, the impacts of nanoparticles to human and environment became the emerging issue of toxicology. In this article, physicochemical properties and toxicities of carbon nanotube, fullerene, quantum dots, and other types of nanomaterials were reviewed and the strategy of risk assessment were suggested based on the frame of chemical assessment.