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Triterpenoids from the Flower of Campsis grandiflora K. Schum. As Human Acyl-CoA: Cholesterol Acyltransferase Inhibitors
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  • Triterpenoids from the Flower of Campsis grandiflora K. Schum. As Human Acyl-CoA: Cholesterol Acyltransferase Inhibitors
  • Triterpenoids from the Flower of Campsis grandiflora K. Schum. As Human Acyl-CoA: Cholesterol Acyltransferase Inhibitors
저자명
Kim. Dong-Hyun,Han. Kyung-Min,Chung. In-Sik,Kim. Dae-Keun,Kim. Sung-Hoon,Kwon. Byoung-Mog,Jeong. Tae-Sook,Park. Mi-Hyun,Ahn. Eun
간행물명
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
권/호정보
2005년|28권 5호|pp.550-556 (7 pages)
발행정보
대한약학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The flower of Campsis grandiflora K. Schum. Was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H$_2$O. From the EtO Ac fraction, seven triterpenoids were isolated through the repeated silica gel, ODS column chromatographies and preparative HPLC. From the result of physico- chemical data including NMR, MS and IR, the chemical structures of the compounds were determined as 3${eta}$-hydroxyolean-12-en-28-oic acid (oleanolic acid, 1), 3${eta}$-hydroxyurs-12-en-28-oic acid (ursolic acid, 2), 3${eta}$-hydroxyurs-12-en-28-al (ursolic aldehyde, 3), 2${alpha}$,3${eta}$-dihydroxyolean-12-en-28-oic acid (maslinic acid, 4), 2${alpha}$,3${eta}$-dihydroxyurs-12-en-28-oic acid (corosolic acid, 5), 3${eta}$,23-dihydroxyurs-12- en-28-oic acid (23-hydroxyursolic acid ,6) and 2${alpha}$,3${eta}$,23-trihydroxyolean-12-en-28- oic acid (arjunolic acid, 7). These teriterpenoids were isolated for the first time from this plant. Also, compounds 4, 5, 6, and 7 revealed relatively high hACAT-1 inhibitory activity with the value of 46.2${pm}$1.1, 46.7${pm}$0.9, 41.5${pm}$1.3 and 60.8${pm}$1.1% at the concentration of 100${mu}$g/mL, respectively.