Macao, a city with three sides bounded by water, is hot and humid in weather in more than six months of a year. This uncomfortable weather induces the frequency of operating air-conditioners. Choice of location for installation of air-conditioner in a building will affect the performance of cooling effect and thermal comfort on the occupants, which in turn will affect the indoor air quality (IAQ) of the building. In the paper, investigation of distribution on carbon dioxide, room air temperature and velocity, as well as air diffusion performance index (ADPI) of a single bedroom in Macao is studied by using the computational fluid dynamics (CFD) software FLOVENT 3.2. Simulations of locating the air-conditioner at 4 different walls will be done and comparisons and analyses of the results will be performed to decide a proper location for the air-conditioner for obtaining good thermal comfort.